How Fast Does It Work? | Gameday Men’s Health

How Soon Does Semaglutide Work?

Semaglutide is an FDA-approved drug to promote weight loss in people who are considered obese and/or overweight. Many individuals will notice a decline in weight 4 or more weeks after treatment begins on a dose of .25 mg.

While Semaglutide has previously been used for individuals with diabetes, it is known for being effective at helping overweight individuals lose weight safely. Learn more about the benefits of Semaglutide, the factors affecting how soon it can work, and whether or not you are a candidate for treatment.

How Quickly Does Semaglutide Work for Weight Loss?

It often is not until 4 or more weeks on a dose of 25 units + that patients will start to see a decline in weight. It’s possible that some individuals might not notice weight loss until close to 6 weeks.

To enhance the benefits of Semaglutide, it’s recommended to combine the weekly injections with exercise and changes in diet. The exact amount of time you might need to receive this treatment will depend on your current health conditions (if any) and if exercise and dietary changes can be adopted permanently to maintain an ideal weight. For example, one study found that when Semaglutide is combined with a low-calorie diet and behavioral therapy, it results in an even more significant amount of weight loss.

Semaglutide is GLP-1 (glucagon-like-peptide-1), a receptor agonist, which means that it mimics the hormone GLP-1 known for regulating hunger, and therefore food intake. When Semaglutide is injected weekly, the hormone is suppressed and gastric emptying is delayed, which results in you feeling much more full and satisfied after eating a meal.

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Factors Affecting How Soon It Will Work

The effectiveness and how quickly Semaglutide works can be influenced by several factors:
  • Dosage:
  • Higher doses could lead to faster results but with increased risk of side effects.

  • Individual Metabolism:
  • People’s bodies process medications differently, affecting how quickly they notice weight loss.

  • Diet and Exercise:
  • Lifestyle changes complement the drug’s effectiveness, potentially enhancing the results.

  • Severity of Condition:
  • Those with mild issues might notice improvements sooner than those with more severe conditions.

  • Adherence to Treatment:
  • Consistency in taking the injections as prescribed is important for noticing the benefits within a 4 to 6-week (or longer) period of time.

  • Combination with Other Medications:
  • Interactions with other drugs can affect how quickly Semaglutide works.


Semaglutide injections are known for offering numerous benefits, including:

  • Significantly reducing weight, especially when combined with following a healthy diet and exercising regularly
  • Providing consistent, safe weight loss over an extended period of time
  • Diminishing risk of heart and cardiovascular disease upon achieving a healthy weight
  • Helping you to look and feel healthier
  • Requiring only one injection per week (often for up to 16 weeks)

Who is a Candidate?

You might be a candidate for Semaglutide injections if the below applies to you. Your healthcare provider will conduct a thorough health evaluation during your initial consultation to determine if you are a candidate.
  • Individuals with type 2 diabetes for blood sugar control
  • Patients needing assistance with weight loss when diet and exercise are insufficient
  • Adults with obesity (BMI ≥30) or overweight (BMI ≥27) with at least one weight-related condition (e.g., hypertension, type 2 diabetes, dyslipidemia)
As mentioned, studies indicate that Semaglutide is most effective when combined with changes to diet and exercise. One study of 1,961 people found that in people with a BMI over 30 and who did not have diabetes, Semaglutide injections combined with exercise resulted in a mean decrease in body weight of 14.9% over 68 weeks. The placebo group saw only a 2.4% mean decrease in weight.

This makes it important to have a willingness to incorporate a healthy diet and regular exercise into your life if you are considering beginning treatment.

What are Potential Side Effects?

The potential side effects will vary based on your current health but can include:
  • Nausea, vomiting, diarrhea
  • Stomach pain, constipation
  • Headaches
  • Fatigue
  • Low blood sugar (in people with diabetes)
Additional side effects, while very rare, can include thyroid tumors, pancreatitis, kidney problems, and gallbladder issues.

Do You Need Help With Weight Loss?

At Gameday, you are our priority. We make up for what other men’s clinics lack in enhancing your health and then take it one step further. We want you to be comfortable during your visit, so we welcome you to relax in our overstuffed chairs while watching sports on our flat-screen TVs.

By receiving your Semaglutide treatments with Gameday, you get to feel confident knowing you’re working with one of the best medical providers for men’s health.

Let us help you get back in the game.

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